الكيفير و السرطان:دراسات علمية مثبتة لفوائده - مدونة غذئيات

المراجع

Kefir type or product

نوع الكيفير أو المنتج

Antitumor /anticarcinogenic effect

الفعالية المضادة للتسرطن والأورام

Cancer type

نوع السرطان

Rizk S, El Khoury N, El-Hayek S, Tarras O, El-sibai M, ElSabban M. (2014;

كفير

Kefir anticancer potential property on CRC cell lines (Caco-2 and HT-29) exhibits the ability of kefir to induce cell cycle arrest at the G1 phase. In addition, kefir decreases the expression of TGF-β1 and TGF-α in HT-29 cell line. Upregulation of the Bax/Bcl-2 ratio supports the pro-apoptotic effect of kefir and increase of p53 independent-p21 expression

Colon cancer

سرطان القولون

56. Can G, Topuz E, Derin D, Durna Z, Aydiner A. 2009.

كفير

kefir can reduce sleep disturbance in patients treated for colorectal cancer.

Ghoneum and Felo

 53. Ghoneum M, Felo N. 2015,

Lactobacillus kefiri

 apoptosis induction in gastric cancer (AGS) cell line. Apoptosis was associated with declined polarization of mitochondrial membrane potential (MMP) and reduced Bcl2 expression. Downregulation of Bcl-2 and decrease in the MMP in AGS cells may lead to release of pro-apoptotic molecules and subsequently activation of caspases, causing apoptosis

Gastric cancer

سرطان المعدة

Gao J, Gu F, Ruan H, Chen Q, He J, He G. 2013

cell-free fraction of Tibetan kefir

kefir halts G1/S phase transition in SGC7901 cell line and induces apoptosis through downregulation of bcl-2 and overexpression of bax

Chen C, Chan HM, Kubow S. 2007

مستخلص الكيفير

effect of extracts of kefir on MCF-7 and HMECs cell lines and demonstrated that kefir depressed MCF-7 cell growth in a dose-dependent manner

Breast cancer

سرطان الثدي

van’t Veer P, Dekker JM, Lamers JW, Kok FJ, Schouten EG, Brants HA, et al. 1989;

de LeBlanc AdM, Matar C, Farnworth E, Perdigon G. 2006;.

مستخلص الكيفير

study of cytokines involved in the prevention of a murine experimental breast cancer by kefir, the modulatory capacity of kefir cell-free fraction (KF) on the immune response in mammary glands and tumors was demonstrated that kefir extracts induce apoptosis, cell cycle arrest and reduce tumor growth in breast cancer cells; therefore, it may be suitable in the prevention or treatment of breast cancer.

52. Nagira T, Narisawa J, Teruya K, Katakura Y, Shim S-Y, K-i Kusumoto, et al. 2002.

كفير

kefir suppressed morphological alterations in melanoma cell lines (HMV-1 and SK-MEL and TIG-1), caused by UVC irradiation

Skin cancer

سرطان الجلد

مستخلص الكيفير

kefir extract application after UVC irradiation of HVM-1 cells resulted in a notable reduction in intracellular reactive oxygen species (ROS), increased by exposure to UVC irradiation. Also, it prevented the generation of thymine dimer, suppressed the apoptosis and rescued HMV-1 cells from cell death caused by UVC irradiation, concluding that application of kefir can inhibit UV damage

Jalali F, Sharifi M, Salehi R.. 2016;

كفير

increased apoptosis and decreased cell proliferation In leukemia

Leukemia

سرطان إبيضاض الدم أو اللوكيميا

Maalouf K, Baydoun E, Rizk S. 2011;

كفير

 significant decrease in cell proliferation in CME and Jurkat (human T lymphotropic virus type I-negative malignant T lymphocyte cell lines), in dose- and time-dependent manner. Kefir displayed an anti-proliferative effect by upregulating TGF-β1 and downregulating TGF-α expression

Rizk S, Maalouf K, Baydoun E.. 2009;

كفير

anti-proliferative effect of kefir on HuT-102 malignant T lymphocytes was demonstrated and the decrease in proliferation was significant and dose and time dependent. Kefir has caused downregulation of TGF-α, which is one of the cytokines, inducing cell proliferation and replication

. Ghoneum M, Gimzewski J. 2014

Lactobacillus kefiri P-IF strain

The apoptotic effect of PFT on human multidrug-resistant myeloid leukemia (HL60/AR cell line) indicated that PFT induced apoptosis in the HL60/AR cell line in a dose-dependent manner. Apoptotic induction was associated with caspase 3 activation, downregulation of Bcl-2 and lower polarization of mitochondrial membrane potential MMP

. Liu J-R, Wang S-Y, Lin Y-Y, Lin C-W. 2002.

soy milk kefir and milk kefir /oral administration

 mice-bearing sarcoma tumor growth was inhibited 64.8% in milk and 70.9% in soy milk kefir group

Sarcoma

 الساركومة

Cevikbas A, Yemni E, Ezzedenn FW, Yardimici T, Cevikbas U, Stohs S. Res. 1994.

. Alsha’ar IA, Aloklah B, Al-Deen RB, Aljamali M, Alkadry R, Albiski F. 2017

alkaline kefir (AK), followed by exo-polysaccharides (EPS), alkaline exo-polysaccharides (AEPS) and kefir,

AK can be used in the treatment of human sarcoma

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polysaccharide (KGF-C) from kefir grains

The KGF-C inhibited the growth of the solid tumor S-180 by 21–81% and 40–59% in Ehrlich carcinoma, compared with the control mice.